Research projects

1

British Lung Foundation/ Allen & Hanburys Research Fellowship Dr Lynne Bingle from the University of Sheffield Medical School, S Yorkshire (N England): 119,875
Research on a new family of proteins involved in COPD. (ref. RF02/11)

2

Dr Alexander Faith, Dr Catherine M Hawrylowicz and Dr Christopher Corrigan from Guy’s, King’s College and St Thomas’ School of Medicine, Greater London: 78,349
A study of cells coordinating allergic responses in the airways of asthma patients. (ref. P02/4)

3

 Dr Ann Millar from Southmead Hospital, Bristol (SW England): 200,000
To look at the inflammatory regulation in the human lung. (ref. p00/1)

4

 Dr Anthony Frew, Dr Donna Davies and Dr S Sam, Southampton General Hospital, Hampshire (S Counties): 119,828
To look at the effects of diesel exhaust particles on chronic asthma. (ref. P00/6)

5

Dr Giovanni Lombardi and Professor Robert Lechler, Hammersmith Hospital, Greater London: 119,935
A project looking at chronic lung disease provoked by metals. (ref. P01/3)

6

Dr Hans Michael Haitchi, Clinical Research Fellow at the University of Southampton
“The role of a new asthma gene (ADAM33) in baby lungs”. 107,000.

7

Dr Helen Parfrey, Specialist Registrar Respiratory at the University of Cambridge School of Clinical Medicine
Trevor Clay Memorial Fund. “To assess the role of the anti-inflammatory molecule alpha1-antitrypsin in pulmonary fibrosis”. 5,000.

9

Dr Ian Pavord and Dr Surrinder Birring, Glenfield Hospital, Leicester, Leicestershire (Midlands): 25,400
(ref. P01/8) To study unexplained chronic cough.

10

Dr Jeremy Allen, Dr Richard Knight and Professor Monica Spiteri from the North Staffordshire Hospital, Stoke-on-Trent, Staffordshire (Midlands): 119,776
Investigating whether turning off genes responsible for scar-tissue formation in pulmonary fibrosis might be effective. (ref. P02/5)

11

Dr Jeremy Brown and Professor Gordon Dougan, Imperial College of Science, Technology and Medicine, Greater London: 87,332
Research on new vaccines to prevent pneumonia (ref. P02/3)

12

Dr Kenneth OByrne, Senior Lecturer and Consultant Medical Oncologist, Leicester Royal Infirmary (Trevor Clay Memorial Grant)
Can the presence of a specific cellular chemical receptor predict which patients will benefit most from a new type of lung cancer treatment?

13

Dr Mark Elliott, Dr Josephine Lightowler and Dr Snowden, St James’s University Hospital, Leeds, W Yorkshire (N England): 35,639 (completed)
To investigate whether continuous monitoring of people with COPD on non-invasive ventilation allows the ventilator to be optimised to the patient’s needs so that it can be used outside intensive care units. (ref. P00/5)

14

Dr Mark Griffiths, Dr Masao Takata and Dr Mark Giembycz from the Royal Brompton Hospital, Greater London: 61,852
Investigating lung injury caused by mechanical ventilation. (ref. P02/10)

15

Dr Mike Morgan, Dr Sarah Deacon and Dr Sally Singh, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicestershire (Midlands):
Investigating whether creatine supplementation improves the effects of exercise training in patients with chronic lung disease. (ref. P02/12

16

Dr Neil Barnes, Professor Peter Jeffery and Dr William Elston from the London Chest Hospital (Greater London): 119,237
To study the effects of cigarette smoking on the lung in asthmatics, and the relationship between COPD and asthma. (ref. P01/9)

17

Dr Peter Bradding and Professor Andrew Wardlaw, Glenfield Hospital, Leicestershire (Midlands): 71,000
To look at the effect of anti-asthma drugs in specialised lung cells found in the tissue and blood (mast cells). (ref. P01/1)

18

Dr Rachel Chambers, Lecturer, University College London
Role of blood clotting factors in fibrotic lung disease

19

Dr Richard Hubbard and Professor John Britton, Nottingham City Hospital, Nottinghamshire (Midlands): 9,557
To explore whether nicotine replacement therapy (NRT) or bupropion for smoking cessation is safe in patients with COPD. (ref. P01/2)

20

Dr Robin McAnulty and Dr Stephen Hart, University College London (Greater London): 77,351
To look at the genetics of pulmonary fibrosis. (ref. P01/4)

21

Dr Robin McAnulty, Reader in Lung Pathobiology, University College London
Understanding pulmonary fibrosis and potential for new treatments. 48,685

22

Dr Robina Coker, Senior Lecturer, Dr R Shiner, Honorary Senior Lecturer and Prof. Martyn Partridge, Professor of Respiratory Medicine at Imperial College London and Hammersmith Hospitals NHS Trust (Joint BLF/ BTS grant)
Outcomes of air travel in people living with respiratory disease

23

Dr Sarah Dunsmore and Dr Felix Chua, Royal Free & University College Medical School, Greater London: 34,163 (completed)
To look at the role of neutrophil elastase, a destructive enzyme, in pulmonary fibrosis. (ref. P00/4)

24

Dr Stephen Pereira, Consultant Physician & Honorary Senior Lecturer at University College London
Trevor Clay Memorial Fund. “The diagnosis and staging of lung cancer using endoscopic ultrasound and fine needle aspiration”. 15,000.

25

Dr Tariq Sethi and Dr A Mackinnon, University of Edinburgh Medical School (Scotland): 116,351
To look at the molecular mechanisms underlying relapse and resistance to chemotherapy in small cell lung cancer. (ref. P00/10)

26

Dr Tariq Sethi, Wellcome Trust Senior Research Leave Fellow and Reader in Medicine and Dr Sarah Howie, Reader in Pathology at the University of Edinburgh
Interactions between lung cancer cells and cells of the immune system which result in immunosuppression and promote the survival of lung cancer cells.

27

Dr Zsuzsanna Tabi, Dr Bharat Jasani and Dr Colin Gelder from the Velindre Hospital, Cardiff, Wales: 108,965
An investigation into immune responses to a virus present in patients with mesothelioma. (ref. P02/6)

28

Mrs Fiona Kellett and Dr Rob Niven from Wythenshawe Hospital, Greater Manchester (NW England): 9,786
Research into improving treatment for bronchiectasis patients (ref. TC02/2)

29

Mrs Susan Cooper, Research Associate, Prof. Anne Tattersfield, Head of Division, and Dr Timothy Harrison, Consultant Physician from City University, Nottingham (Trevor Clay Memorial Grant)
Does taping the mouth at night have an effect on asthma control?

30

Prof. Edwin Chilvers, Professor of Respiratory Medicine, Dr Karen Cadwallader, Senior Research Associate and Dr Andres Floto, Clinical Scientist at the University of Cambridge
Mechanisms underlying the regulation of inflammatory cell activation

31

Prof. Jadwiga Wedzicha, Professor of Respiratory Medicine, Dr Terence Seemungal, Senior Research Fellow and Dr Gavin Donaldson, Non-clinical Lecturer in Respiratory Medicine at St Bartholomews and the London Medical School
Does long-term macrolide (antibiotic) therapy improve outcome in people living with COPD by reducing the frequency of chest episodes or exacerbations?

32

Prof. John Moxham, Professor of Respiratory Medicine at Kings College London (Trevor Clay Memorial Grant)
Exercise therapy following hospital admission with COPD

33

Professor Chris Griffiths, Professor Gene Feder, Dr Choudry, Dr Geoff Packe and Dr Jadwiga Wedzicha, Queen Mary and Westfield College, Greater London: 133,057
To look at the withdrawal of inhaled corticosteroids in patients with COPD in general practice. (ref. P00/8)

34

Professor Dennis Shale, Dr Alina Ionescu and Professor David Owens, Llandough Hospital, Cardiff (Wales): 119,690
To look at weight control in COPD. (ref. P01/7)

35

Professor Graham Rook, Dr Keertan Dheda and Dr Margaret Johnston from the Royal Free and University College Medical School, Greater London: 119,833
An investigation of the immune response caused by tuberculosis-causing bacteria. (ref. P02/9)

36

Professor Hannah Gould and Dr David Fear, of Guys, Kings and St Thomass School of Biomedical Sciences, Greater London: 77,117
To analyse the genetic mechanisms which lead to the production of allergen specific antibodies in the initiation of an allergic reaction in asthma. (ref. P00/7)

37

Professor John Moxham, Dr Julia Wendon and Dr Michael Polkey from King’s College Hospital, Greater London: 100,107
To help intensive care unit patients breathe without the need for ventilators. (ref. P02/7)

38

Professor Ken Reid from the University of Oxford (Northern Home Counties): 59,361
A project on how two lung proteins interact with cells of the immune system to suppress an excessive response to inhaled allergens. (ref. P01/5)

39

Professor KK Cheng, Professor Jon Ayres and Dr Jeremy Hawker, University of Birmingham (Midlands): 119,870
To explore risk factors for hospitalisation amongst the elderly with acute respiratory infections during the Winter. (ref. P01/10)

40

Professor Marlene Rose from Harefield Hospital, Middlesex (Greater London): 35,903
To gain an understanding of chronic rejection after lung transplantation. (ref. P01/6)

41

Professor Paul Corris, Freeman Hospital, Newcastle-upon-Tyne (N England): 33,163
To investigate whether patients at risk of developing chronic lung reaction after a lung transplant can be identified by examining their sputum. (ref. P00/3)

42

Professor Sebastian Johnston from Imperial College School of Medicine, Greater London: 200,000
To explore the interaction between respiratory viral infections, immunity, asthma and COPD. (ref. P00/2)

43

Professor Terence Stephenson, Dr Anna Maria Atkinson, Dr Monica Lakhanpaul and Dr Alan Smyth from Nottingham University Hospital, Nottinghamshire (Midlands): 84,834
Research on the treatment of childhood pneumonia in hospital and at home. (ref. P02/8)

44

Trevor Clay Memorial Fund Dr Jadwiga Wedzicha and Professor R Reznek, St Bartholomew’s Hospital, Greater London: 10,000 (completed)
To look at whether COPD patients at risk of increased exacerbations can be identified by a type of X-ray known as computerised tomography (CT) scanning. (ref. TC00/12)

45

Trevor Clay Memorial Fund Dr Sally Singh and Dr Mike Morgan, of Glenfield Hospital NHS Trust, Leicestershire (Midlands): 9,895 (completed)
To clarify the dose response curve to pulmonary rehabilitation. (ref. TC00/11)

46

Trevor Clay Memorial Fund Grants Professor Duncan Geddes and Dr Tudor P Toma, Royal Brompton Hospital, Greater London: 9,000
Research on a new treatment for patients with severe emphysema. (ref. TC02/1)

47

Trevor Clay Memorial Grant Fund Dr Hilary Pinnock and Dr Aziz Sheikh, Whistable Health Centre, Kent (S Counties): 10,000 (completed)
A randomised controlled trial comparing the clinical and cost effectiveness of telephone consultations with face-to-face consultations in the management of adult asthmatics in primary care. (ref. TC00/9)

48

Dr Charlotte Dean, MRC Mammalian Genetics Unit, Harwell
Title: A Developmental Approach to Understanding Lung Disease Lay title: Uncovering genes responsible for lung disease

49

Dr Helen Marriott, University of Sheffield
Title: Molecular analysis of the effects of influenza A virus on macrophage innate immune infection Lay Title: How does influenza alter our defences against other lung infections?

50

Dr Mark Paul-Clark, Imperial College London
Title: Sensing of oxidative stress by the innate immune system in inflammatory lung disease Lay title: Understanding how the lung recognises and deals with specific irritants in the air

51

Dr Jeremy Brown, Royal Free and UCL Medical School
Title: Mechanisms of protection and efficacy of novel Streptococcus pneumoniae vaccines based on lipoprotein components of ABC transporters Lay title: Better vaccines for preventing a common cause of pneumonia and other chest infections

52

 Dr Graham Roberts, University of Southampton
Title: The influence of maternal nutrition and fetal growth on childhood airway structure and atopy Lay title: Does a mothers nutrition during pregnancy affect the development of asthma and other wheezing illnesses in her child?

53

Dr Tyson Sharp, University of Nottingham
Title: Characterization of the expression of the novel tumour suppressor LIMD1; a marker for lung carcinogenesis? Lay Title: Characterisation of a novel gene involved in lung cancer.

54

 Dr Len Stephens, Babraham Institute, Cambridge
Title: Role of the Small GTPase RhoG in Neutrophil Activation Lay title: Lung Damage Due to White Blood Cells: Can We Prevent It?

55

Professor Mike Barer, University of Leicester
Targeting refractory cell populations in tuberculosis by monitoring mycobacterial lipid bodies.

56

Dr Adrian Martineau, Queen Mary, University of London
Does vitamin D decrease infectiousness in lung TB? A clinical trial

57

Professor Martin Partridge, Imperial College London
The Development of an Interactive Electronic Pictorial Asthma (and subsequently COPD) treatment action plan

58

Dr Sally Singh, University of Leicester
A self-management programme for COPD; is it a feasible alternative to conventional pulmonary rehabilitation?

59

Dr Alison Mackinnon Senior Postdoctoral Scientist at the University of Edinburgh
Title: Neuropeptide receptors as a therapeutic target in small cell lung cancer.

60

Dr Andrea Venn Lecturer in Epidemiology and Professor John Britton Professor of Epidemiology at the University of Nottingham
Title: Does living close to a main road increase the risk of asthma, allergy or chronic airflow obstruction?

61

Dr Anne Bruton DoH Postdoctoral Research Fellow, Claire OSullivan Lecturer in Physiotherapy and Denise Gibson Senior Physiotherapist at the University of Southampton
Title: The effects of a 4-week programme of physiotherapy breathing retraining on patients with either asthma or hyperventilation syndrome.

62

Dr Howard Clark MRC Scientist, Dr Annelyse Duvoix Post doctoral research scientist and Prof Kenneth Reid FRS MRC Unit director at the University of Oxford
Title: Investigation of the mechanisms by which surfactant protein D prevents the development of pulmonary emphysema.

63

 Dr Hugh Montgomery Senior Lecturer in Cardiovascular Genetics, UCLConsultant Intensivist, UCLH Director UCL Centre for Health and Human Performance, Dr Nicholas S. Hopkinson Wellcome Research Fellow and Dr William D-C. Man MRC Clinical Research
Title: ACE Geneotype in COPD and response to pulmonary rehabilitation.

64

Dr John Earis Consultant Physician Hon Senior Lecturer and Dr Raffaele Dellaca Research Fellow at University Hospital Aintree, Liverpool
Title: The use of Active and Passive Sound in the identification and monitoring of COPD.

65

Dr Luminita Stanciu Senior Research Fellow and Prof Sebastian L Johnston Professor of Respiratory Medicine at Imperial College London
Title: Role of the novel co-stimulatory molecules PD-L1 and PD-L2 in regulating CD8+ T cell responses to RSV infection.

66

Dr Mohib Uddin Senior Research Fellow, Dr. Ratko Djukanović Senior Lecturer Medicine and Dr. Donna Elizabeth Davies Reader in Respiratory Cell & Molecular Biology at the University of Southampton
Title: An investigation into mechanisms regulating neutrophil-bronchial epithelium interactions in moderate to severe asthma.

67

Dr Seif Shaheen Senior Lecturer in Epidemiology, Prof Marcus Pembrey Director of Genetics, ALSPAC (Professor of Paediatric Genetics) Dr John Henderson Consultant Senior Lecturer in Child Health and Dr John Holloway Senior Research Fellow at Kings Co
Title: How do genes modify the prenatal and postnatal effects of tobacco smoke, paracetamol and antioxidant exposure on childhood respiratory outcomes?

68

Dr Stephen Ellis Consultant Thoracic Radiologist and Dr Lieske Kuitert Consultant Respiratory Physician at the Royal London Hospital
Title: Prospective study of the incidence of pulmonary embolism (PE) in patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease (COPD).

69

Professor Andrew Bush, Professor of Paediatric Respirology & Honorary Consultant Paediatric Chest Physician, Professor Peter Barnes Professor of Thoracic Medicine, Dr Nicola Wilson Hon Consultant Paediatrician, Royal Brompton & Harefield NHS Trust an
Title: Prospective, randomised controlled trial of the use of inflammatory markers to guide therapy in children with severe asthma.

70

Professor John Moxham Professor of Respiratory Medicine, Dr Michael Polkey Consultant Physician & Reader in Respiratory Medicine and Dr William Man MRC Clinical Research Fellow at Kings College Hospital London
Title: Early Pulmonary Rehabilitation Following Hospitalisation For Acute Exacerbations of COPD.

71

Professor Peter Calverley Professor of Respiratory Medicine at the University of Liverpool
Title: Role of abnormal chest wall movement and tidal flow limitation in impairing exercise capacity in COPD.

72

Dr Ian Balfour-Lynn, Imperial College London
Dr Ian Balfour-Lynn, Imperial College London Study of babies and children who need oxygen at home Amount awarded: 14,972 Relevant diseases: Chronic neonatal lung disease, Cystic fibrosis, Paediatric interstitial lung disease, Pulmonary hypertension.

73

Dr Michael Edwards, Imperial College London
Dr Michael Edwards, Imperial College London Preventing asthma attacks triggered by the common cold Amount awarded: 119,979 Relevant diseases: Asthma

74

P06/12 Dr Linhua Pang, University of Nottingham
P06/12 Dr Linhua Pang, University of Nottingham Unravelling the mechanisms of scar formation in idiopathic pulmonary fibrosis Amount awarded: 107,741 Relevant diseases: Idiopathic pulmonary fibrosis

75

Dr Kenneth Bruce, Kings College London
Dr Kenneth Bruce, Kings College London What microbes are important in causing long term lung disease in very young children? Amount awarded: 63,003 Relevant diseases: Chronic neonatal lung disease.

76

Dr Robert Davies, University of Oxford
Dr Robert Davies, University of Oxford A clinical trial to try to improve the treatment of patients with cancer induced fluid accumulation in the chest by using an indwelling chest tube to control symptoms. Amount awarded: 112,552 Relevant diseases: Mesothelioma, Lung Cancer

77

Professor Janet Stocks, University College London
Professor Janet Stocks, University College London The effect of prematurity on lung development: which infants are most at risk? Amount awarded: 119,982 Relevant diseases: Chronic lung disease of infancy, respiratory distress, Bronchopulmonary dysplasia, prematurity

78

Dr Melanie Newport, University of Sussex
Dr Melanie Newport, University of Sussex Finding new drugs for tuberculosis, an emerging old disease Amount awarded: 70,470 Relevant diseases: Tuberculosis.

79

Dr Sejal Saglani, Imperial College London
Dr Sejal Saglani, Imperial College London Exploring the link between onset of airway scarring, inflammation and abnormal lung function in asthma Amount awarded: 119,527 Relevant diseases: Asthma.

80

Dr Albiruni Ryan Abdul Razak, University of Newcastle, MICK KNIGHTON AWARD
Dr Albiruni Ryan Abdul Razak, University of Newcastle Developing tests of mesothelioma samples to find out which patients will benefit from chemotherapy Amount awarded: 87,395 Relevant diseases: Mesothelioma

81

Dr Zsuzsanna Tabi, Cardiff University, JUNE HANCOCK AWARD
Dr Zsuzsanna Tabi, Cardiff University Anti-tumour immune cells in mesothelioma Amount awarded: 138,119 Relevant diseases: Mesothelioma

82

Dr Ling-Pei Ho, University of Oxford, HENRY SHELFORD AWARD
Dr Ling-Pei Ho, University of Oxford Understanding the genetics of sarcoidosis Amount awarded: 50,082